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Open Access
Peer-reviewed
Research Article
UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein
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Tian Xia,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation College of Basic Medicine, Chongqing Medical University, China
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Min Luo,
Roles Data curation, Formal analysis, Methodology, Validation
Affiliation Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China
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Yuncheng Wang,
Roles Data curation, Formal analysis, Validation
Affiliation College of Basic Medicine, Chongqing Medical University, China
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Yaping Qin,
Roles Data curation, Formal analysis
Affiliation Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
⨯ - Xiaoning Li,
- Shuying Chen,
- Junqi Xiang,
- Shanrong Yang,
- Yaokai Wang,
- Jing Zhu,
- Bo Yang,
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Li Lin,
Roles Validation
Affiliation Department of Respiratory Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, China
⨯ - Jiajun Yan,
- Yunxiao Dou,
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Jian Shang,
Roles Methodology
Affiliation Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
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Na Zang,
Roles Funding acquisition, Methodology
Affiliation Department of Respiratory Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, China
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Yong Lin,
Roles Resources
Affiliation Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Chongqing Medical University, China
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Xiaohong Yao ,
Roles Funding acquisition, Resources
* E-mail: yswan@cqmu.edu.cn (YW); yxh15@163.coms (XY)
Affiliation Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China
⨯ - [ ... ],
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Yushun Wan
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: yswan@cqmu.edu.cn (YW); yxh15@163.coms (XY)
Affiliations College of Basic Medicine, Chongqing Medical University, China, Department of Respiratory Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, China
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UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein
- Tian Xia,
- Min Luo,
- Yuncheng Wang,
- Yaping Qin,
- Xiaoning Li,
- Shuying Chen,
- Junqi Xiang,
- Shanrong Yang,
- Yaokai Wang,
- Jing Zhu
- Published: October 14, 2025
- https://doi.org/10.1371/journal.ppat.1013593