Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus

Jennifer McIntyre; Alison Morrison; Kirsty Maitland; Eileen Devaney; James A. Cotton; Collette Britton; Ray M. Kaplan; Dave Bartley; Roz Laing

doi:10.1371/journal.ppat.1013578

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Peer-reviewed

Research Article

Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus

Jennifer McIntyre ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Jennifer.McIntyre@glasgow.ac.uk (JM); Rosalind.Laing@glasgow.ac.uk (RL)

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Alison Morrison,

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliation Moredun Research Institute, Pentlands Science Park, Penicuik, United Kingdom
⨯
Kirsty Maitland,

Roles Investigation, Methodology

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Eileen Devaney,

Roles Conceptualization, Writing – review & editing

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
James A. Cotton,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Collette Britton,

Roles Conceptualization, Writing – review & editing

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Ray M. Kaplan,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation School of Veterinary Medicine, St. George’s University, True Blue, Grenada, West Indies
⨯
Dave Bartley,

Roles Conceptualization, Investigation, Resources

Affiliation Moredun Research Institute, Pentlands Science Park, Penicuik, United Kingdom
⨯
Roz Laing

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: Jennifer.McIntyre@glasgow.ac.uk (JM); Rosalind.Laing@glasgow.ac.uk (RL)

Affiliation School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom

https://orcid.org/0000-0002-6191-0759

⨯

Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus

Jennifer McIntyre,
Alison Morrison,
Kirsty Maitland,
Eileen Devaney,
James A. Cotton,
Collette Britton,
Ray M. Kaplan,
Dave Bartley,
Roz Laing

Published: October 6, 2025
https://doi.org/10.1371/journal.ppat.1013578

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Drug therapy
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Genetic loci
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Eggs
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Larvae
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Nucleotides
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Lactones
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Single nucleotide polymorphisms
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