HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission

Florian Simon; Norbert Donhauser; Laura M. Kemeter; Franziska Wittdorf; Sebastian Millen; Heinrich Sticht; Andrea K. Thoma-Kress

doi:10.1371/journal.ppat.1013570

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Open Access

Peer-reviewed

Research Article

HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission

Florian Simon,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
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Norbert Donhauser,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
⨯
Laura M. Kemeter,

Roles Investigation, Validation, Writing – review & editing

Affiliation Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
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Franziska Wittdorf,

Roles Investigation, Validation, Writing – review & editing

Affiliation Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
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Sebastian Millen,

Roles Investigation, Validation, Writing – review & editing

Affiliation Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
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Heinrich Sticht,

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliations Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, FAU Profile Center Immunomedicine (FAU I-MED), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
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Andrea K. Thoma-Kress

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: andrea.thoma-kress@uk-erlangen.de

Affiliations Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, FAU Profile Center Immunomedicine (FAU I-MED), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

https://orcid.org/0000-0002-8568-9526

⨯

HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission

Florian Simon,
Norbert Donhauser,
Laura M. Kemeter,
Franziska Wittdorf,
Sebastian Millen,
Heinrich Sticht,
Andrea K. Thoma-Kress

Published: October 10, 2025
https://doi.org/10.1371/journal.ppat.1013570

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HTLV-1
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Signal peptides
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T cells
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Transfection
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Membrane proteins
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293T cells
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Protease inhibitors
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Viral transmission and infection
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