Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

Xingyu Ren; Jing Bai; Yingying Han; Jiaying Xu; Yingchen Liu; Zhiqing Ma; Yong Wang; Juntao Feng

doi:10.1371/journal.ppat.1013567

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Peer-reviewed

Research Article

Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

Xingyu Ren,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations College of plant protection, Northwest A&F University, Yangling, Shaanxi China, Engineering and Research Center of Biological Pesticide of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi China
⨯
Jing Bai,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation College of plant protection, Northwest A&F University, Yangling, Shaanxi China
⨯
Yingying Han,

Roles Data curation, Investigation, Methodology, Validation

Affiliation College of plant protection, Northwest A&F University, Yangling, Shaanxi China
⨯
Jiaying Xu,

Roles Data curation, Methodology, Validation

Affiliation College of plant protection, Northwest A&F University, Yangling, Shaanxi China
⨯
Yingchen Liu,

Roles Investigation, Methodology

Affiliation College of plant protection, Northwest A&F University, Yangling, Shaanxi China
⨯
Zhiqing Ma,

Roles Conceptualization, Resources

Affiliations College of plant protection, Northwest A&F University, Yangling, Shaanxi China, Engineering and Research Center of Biological Pesticide of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi China
⨯
Yong Wang ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: fengjt@nwafu.edu.cn (JF); wy2010102163@163.com (YW)

Affiliations College of plant protection, Northwest A&F University, Yangling, Shaanxi China, Engineering and Research Center of Biological Pesticide of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi China
⨯
Juntao Feng

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: fengjt@nwafu.edu.cn (JF); wy2010102163@163.com (YW)

Affiliations College of plant protection, Northwest A&F University, Yangling, Shaanxi China, Engineering and Research Center of Biological Pesticide of Shaanxi Province, Northwest A&F University, Yangling, Shaanxi China

https://orcid.org/0000-0002-5320-1178

⨯

Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis

Xingyu Ren,
Jing Bai,
Yingying Han,
Jiaying Xu,
Yingchen Liu,
Zhiqing Ma,
Yong Wang,
Juntao Feng

Published: October 3, 2025
https://doi.org/10.1371/journal.ppat.1013567

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