Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice

• Juan-María Torres ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jmtorres@inia.csic.es (J-MT); legname@sissa.it (GL)

  Affiliation Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain

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• Alba Marín-Moreno,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain

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• Juan-Carlos Espinosa,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain

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• Sara Canoyra,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC: Consejo Superior de Investigaciones Cientificas, Valdeolmos, Madrid, Spain, Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense de Madrid UCM, Madrid, Spain

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• Anna Burato,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy

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• Arianna Ciullini,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Unit of Laboratory of Medicine – Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

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• Chiara Maria Giulia De Luca,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

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• Edoardo Bistaffa,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Division of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

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• Fabio Moda,

  Roles Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Unit of Laboratory of Medicine – Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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• Giuseppe Legname

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jmtorres@inia.csic.es (J-MT); legname@sissa.it (GL)

  Affiliations Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy, ELETTRA Sincrotrone Trieste S.C.p.A, Basovizza, Trieste, Italy

  https://orcid.org/0000-0003-0716-4393

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