The tegument protein VP22 of pseudorabies virus inhibits cGAS condensation by inducing nuclear-to-cytoplasmic translocation of DDX21

• Kesen Liu ,

  Contributed equally to this work with: Kesen Liu, Wandi Cao, Hanhua Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

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• Wandi Cao ,

  Contributed equally to this work with: Kesen Liu, Wandi Cao, Hanhua Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

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• Hanhua Zhang ,

  Contributed equally to this work with: Kesen Liu, Wandi Cao, Hanhua Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

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• Xingmiao Yang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China

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• Chengyue Wu,

  Roles Validation, Writing – review & editing

  Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

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• Xingya Wang,

  Roles Validation, Writing – review & editing

  Affiliation Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

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• Qian Sun,

  Roles Validation, Writing – review & editing

  Affiliation Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China

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• Jianxiong Guo ,

  Roles Project administration, Validation, Writing – review & editing

  * E-mail: xingliu@njau.edu.cn (XL); liu820512@163.com (YL); Tingzhang9797@163.com (TZ); gjx18700858739@163.com (JG)

  Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China

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• Ting Zhang ,

  Roles Project administration, Writing – review & editing

  * E-mail: xingliu@njau.edu.cn (XL); liu820512@163.com (YL); Tingzhang9797@163.com (TZ); gjx18700858739@163.com (JG)

  Affiliation Shenzhen Health Administrative Center for Cadre and Talent, Shenzhen, China

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• Yan Liu ,

  Roles Project administration, Writing – review & editing

  * E-mail: xingliu@njau.edu.cn (XL); liu820512@163.com (YL); Tingzhang9797@163.com (TZ); gjx18700858739@163.com (JG)

  Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China

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• Xing Liu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: xingliu@njau.edu.cn (XL); liu820512@163.com (YL); Tingzhang9797@163.com (TZ); gjx18700858739@163.com (JG)

  Affiliations Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China

  https://orcid.org/0000-0003-3655-5000

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