Commensal to pathogen switch in Streptococcus pneumoniae is influenced by a thermosensing master regulator

Shruti Apte; Greicy K. Bonifacio-Pereira; Sourav Ghosh; Srijit Kumar Mandal; Leena Badgujar; Krithika Gosavi; Elizabeth Pohler; Thomas E. Barton; Sian Pottenger; Alice Blake; Pradeepkumar PI; Daniel R. Neill; Anirban Banerjee

doi:10.1371/journal.ppat.1013545

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Open Access

Peer-reviewed

Research Article

Commensal to pathogen switch in Streptococcus pneumoniae is influenced by a thermosensing master regulator

Shruti Apte,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Greicy K. Bonifacio-Pereira,

Roles Data curation, Formal analysis, Investigation

Affiliation Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Sourav Ghosh,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Srijit Kumar Mandal,

Roles Data curation, Investigation, Validation

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Leena Badgujar,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Krithika Gosavi,

Roles Conceptualization, Investigation

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Elizabeth Pohler,

Roles Investigation

Affiliation Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Thomas E. Barton,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Sian Pottenger,

Roles Investigation

Affiliation Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom
⨯
Alice Blake,

Roles Investigation

Affiliation Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Pradeepkumar PI,

Roles Methodology

Affiliation Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
⨯
Daniel R. Neill,

Roles Formal analysis, Project administration, Resources, Validation, Writing – review & editing

Affiliation Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Anirban Banerjee

Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: abanerjee@iitb.ac.in

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India

https://orcid.org/0000-0002-4229-5981

⨯

Commensal to pathogen switch in Streptococcus pneumoniae is influenced by a thermosensing master regulator

Shruti Apte,
Greicy K. Bonifacio-Pereira,
Sourav Ghosh,
Srijit Kumar Mandal,
Leena Badgujar,
Krithika Gosavi,
Elizabeth Pohler,
Thomas E. Barton,
Sian Pottenger,
Alice Blake

Published: September 30, 2025
https://doi.org/10.1371/journal.ppat.1013545

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