A single amino acid variant in the variable region I of AAV capsid confers liver detargeting

• Ruxiao Xing ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  ¶‡ Co-first authors.

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Mengyao Xu ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  ¶‡ Co-first authors.

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Darcy Reil,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• April Destefano,

  Roles Investigation, Methodology

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Mengtian Cui,

  Roles Methodology, Resources, Software

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Nan Liu,

  Roles Investigation, Methodology

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Jialing Liang,

  Roles Investigation, Methodology

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Guangchao Xu,

  Roles Resources

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Li Luo,

  Roles Resources

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Meiyu Xu,

  Roles Investigation, Methodology

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Fang Zhang,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Phillip W.L. Tai,

  Roles Methodology, Resources, Software

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Yuquan Wei,

  Roles Resources

  Affiliation State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

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• Alisha M. Gruntman,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Terence R. Flotte,

  Roles Funding acquisition, Resources

  Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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• Guangping Gao ,

  Roles Funding acquisition, Supervision

  * E-mail: Dan.Wang@umassmed.edu (DW); Guangping.Gao@umassmed.edu (GG)

  Affiliations Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America, Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

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•  [ ... ],
• Dan Wang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

  * E-mail: Dan.Wang@umassmed.edu (DW); Guangping.Gao@umassmed.edu (GG)

  Affiliations Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

  https://orcid.org/0000-0001-9079-2360

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