The F1148 hydrophobic lock: A critical determinant of SARS-CoV-2 spike protein-mediated membrane fusion via the 3H/CH cavity

• Fuzhi Lei,

  Roles Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Fudan University, Shanghai, China

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• Yahan Lei,

  Roles Investigation, Validation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Fudan University, Shanghai, China

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• Zhenghong Yuan ,

  Roles Project administration, Resources, Supervision

  * E-mail: zhyuan@shmu.edu.cn (ZY); zgyi@fudan.edu.cn (ZY)

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Fudan University, Shanghai, China

  https://orcid.org/0000-0003-0268-4891

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• Zhigang Yi

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: zhyuan@shmu.edu.cn (ZY); zgyi@fudan.edu.cn (ZY)

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai public health clinical center, Fudan University, Shanghai, China

  https://orcid.org/0000-0002-4560-4970

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