The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture

• Ann-Kathrin Mehnert,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliations Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany, Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany

  https://orcid.org/0000-0001-8935-2894

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• Sebastian Stegmaier ,

  Contributed equally to this work with: Sebastian Stegmaier, Carlos Ramirez Alvarez

  Roles Formal analysis, Investigation, Methodology

  Affiliations Faculty of Biosciences, Heidelberg University, Heidelberg, Germany, Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response”, Division Virus-Associated Carcinogenesis (D430), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Carlos Ramirez Alvarez ,

  Contributed equally to this work with: Sebastian Stegmaier, Carlos Ramirez Alvarez

  Roles Data curation, Formal analysis, Investigation, Methodology, Software

  Affiliation Institute for Pharmacy and Molecular Biotechnology, Heidelberg University & BioQuant, Heidelberg, Germany

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• Elif Toprak,

  Roles Methodology

  Affiliations Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany, Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany

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• Vladimir Gonçalves Magalhães,

  Roles Methodology

  Affiliation Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response”, Division Virus-Associated Carcinogenesis (D430), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Carla Siebenkotten,

  Roles Methodology

  Affiliation Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany

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• Jungen Hu,

  Roles Formal analysis, Methodology

  Affiliations Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany, Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany

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• Ana Luisa Costa,

  Roles Formal analysis, Methodology, Software

  Affiliation Institute for Pharmacy and Molecular Biotechnology, Heidelberg University & BioQuant, Heidelberg, Germany

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• Daniel Kirrmaier,

  Roles Resources

  Affiliations Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany, Division Cell Morphogenesis and Signal Transduction (A260), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Michael Knop,

  Roles Resources

  Affiliations Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany, Division Cell Morphogenesis and Signal Transduction (A260), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Xianfang Wu,

  Roles Resources

  Affiliation Infection Biology Program and Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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• Thibault Tubiana,

  Roles Data curation, Investigation, Software

  Affiliation Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France

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• Carl Herrmann ,

  Roles Data curation, Formal analysis, Supervision

  * E-mail: Carl.Herrmann@uni-heidelberg.de (CH); VietLoan.DaoThi@med.uni-heidelberg.de (VLDT)

  Affiliation German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany

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• Marco Binder,

  Roles Supervision

  Affiliation Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response”, Division Virus-Associated Carcinogenesis (D430), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Viet Loan Dao Thi

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Carl.Herrmann@uni-heidelberg.de (CH); VietLoan.DaoThi@med.uni-heidelberg.de (VLDT)

  Affiliations Schaller Research Group, Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany, German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany

  https://orcid.org/0000-0003-2293-3592

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