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Open Access
Peer-reviewed
Research Article
Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses
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Meng-Ze Tian ,
Contributed equally to this work with: Meng-Ze Tian, Yang-Yang Wang
Roles Investigation, Writing – original draft
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Yang-Yang Wang ,
Contributed equally to this work with: Meng-Ze Tian, Yang-Yang Wang
Roles Investigation, Writing – original draft
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Bao-Jie Cui,
Roles Software
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
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Xiao Xu,
Roles Validation
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
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Chu-Jing Zhou,
Roles Software
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
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Can Zhang,
Roles Software
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Zhuo-Cong Li,
Roles Validation
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Meng-Qian Hong,
Roles Software
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Na Xu,
Roles Validation
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Dan-Dan Chen,
Roles Supervision
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Long-Feng Lu ,
Roles Funding acquisition, Writing – review & editing
* E-mail: llf@ihb.ac.cn (L-FL); bob@ihb.ac.cn (SL)
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Shun Li
Roles Funding acquisition, Writing – review & editing
* E-mail: llf@ihb.ac.cn (L-FL); bob@ihb.ac.cn (SL)
Affiliations Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, College of Fisheries and Life Science, Dalian Ocean University, Dalian, China, Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China, Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan, China
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Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses
- Meng-Ze Tian,
- Yang-Yang Wang,
- Bao-Jie Cui,
- Xiao Xu,
- Chu-Jing Zhou,
- Can Zhang,
- Zhuo-Cong Li,
- Meng-Qian Hong,
- Na Xu,
- Dan-Dan Chen
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- Published: September 12, 2025
- https://doi.org/10.1371/journal.ppat.1013512