TfR1 facilitates influenza virus endocytosis and uncoating by interacting with NA and M1 via extracellular and intracellular domains

Xinchen Wang; Yuanhao Li; Dezhong Ji; Yiming Wang; Xiaoyang Wang; Kangming Guo; Mengyang Wang; Yu Mu; Chen Qin; Tao Yuan; Yuanjie Zhang; Zhiqian Chen; Xingxing Zhu; Xiaohui Zhang; Honghui Jiang; Qiuchen He; Chuanling Zhang; Sulong Xiao; Lihe Zhang; Demin Zhou

doi:10.1371/journal.ppat.1013511

Loading metrics

Open Access

Peer-reviewed

Research Article

TfR1 facilitates influenza virus endocytosis and uncoating by interacting with NA and M1 via extracellular and intracellular domains

Xinchen Wang ,

Contributed equally to this work with: Xinchen Wang, Yuanhao Li, Dezhong Ji, Yiming Wang

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China, Peking University-Yunnan Baiiyao International Medical Research Center, Beijing, China
⨯
Yuanhao Li ,

Contributed equally to this work with: Xinchen Wang, Yuanhao Li, Dezhong Ji, Yiming Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China, Peking University-Yunnan Baiiyao International Medical Research Center, Beijing, China
⨯
Dezhong Ji ,

Contributed equally to this work with: Xinchen Wang, Yuanhao Li, Dezhong Ji, Yiming Wang

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: jidezhong@bjmu.edu.cn (DJ), slxiao@bjmu.edu.cn (SX), deminzhou@bjmu.edu.cn (DZ)

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China, Peking University-Yunnan Baiiyao International Medical Research Center, Beijing, China
⨯
Yiming Wang ,

Contributed equally to this work with: Xinchen Wang, Yuanhao Li, Dezhong Ji, Yiming Wang

Roles Data curation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Xiaoyang Wang,

Roles Data curation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Kangming Guo,

Roles Data curation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Mengyang Wang,

Roles Methodology

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Yu Mu,

Roles Data curation

Affiliation Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China
⨯
Chen Qin,

Roles Data curation

Affiliation Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Tao Yuan,

Roles Data curation, Funding acquisition

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Yuanjie Zhang,

Roles Conceptualization, Validation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Zhiqian Chen,

Roles Conceptualization, Data curation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Xingxing Zhu,

Roles Data curation

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Xiaohui Zhang,

Roles Methodology

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
⨯
Honghui Jiang,

Roles Data curation, Funding acquisition

Affiliation Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Qiuchen He,

Roles Conceptualization

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China
⨯
Chuanling Zhang,

Roles Conceptualization, Methodology

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Peking University-Yunnan Baiiyao International Medical Research Center, Beijing, China
⨯
Sulong Xiao ,

Roles Conceptualization

* E-mail: jidezhong@bjmu.edu.cn (DJ), slxiao@bjmu.edu.cn (SX), deminzhou@bjmu.edu.cn (DZ)

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
Lihe Zhang,

Roles Conceptualization

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China
⨯
[ ... ],
Demin Zhou

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: jidezhong@bjmu.edu.cn (DJ), slxiao@bjmu.edu.cn (SX), deminzhou@bjmu.edu.cn (DZ)

Affiliations State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China, Peking University Ningbo Institute of Marine Medicine, Ningbo, China, Peking University-Yunnan Baiiyao International Medical Research Center, Beijing, China

https://orcid.org/0000-0003-0339-0959

⨯
[ view all ]
[ view less ]

TfR1 facilitates influenza virus endocytosis and uncoating by interacting with NA and M1 via extracellular and intracellular domains

Xinchen Wang,
Yuanhao Li,
Dezhong Ji,
Yiming Wang,
Xiaoyang Wang,
Kangming Guo,
Mengyang Wang,
Yu Mu,
Chen Qin,
Tao Yuan

Published: October 10, 2025
https://doi.org/10.1371/journal.ppat.1013511

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Influenza A virus
Is the Subject Area "Influenza A virus" applicable to this article?

Thanks for your feedback.
Endocytosis
Is the Subject Area "Endocytosis" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Influenza viruses
Is the Subject Area "Influenza viruses" applicable to this article?

Thanks for your feedback.
Sialic acids
Is the Subject Area "Sialic acids" applicable to this article?

Thanks for your feedback.
293T cells
Is the Subject Area "293T cells" applicable to this article?

Thanks for your feedback.
Plasmid construction
Is the Subject Area "Plasmid construction" applicable to this article?

Thanks for your feedback.
H1N1
Is the Subject Area "H1N1" applicable to this article?

Thanks for your feedback.