Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1

Jing Chen; Peiheng Li; Letian Li; Ju Li; Yuhang Jiang; Wancheng Zou; Pengfei Hao; Zihan Gao; Jiayi Hao; Xiaoshuang Shi; Dongliang Fei; Mingxiao Ma; Guoqing Wang; Chang Li

doi:10.1371/journal.ppat.1013495

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Open Access

Peer-reviewed

Research Article

Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1

Jing Chen,

Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Peiheng Li,

Roles Methodology

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Letian Li,

Roles Visualization

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Ju Li,

Roles Methodology

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China
⨯
Yuhang Jiang,

Roles Methodology

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Wancheng Zou,

Roles Methodology

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Pengfei Hao,

Roles Visualization

Affiliations State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Zihan Gao,

Roles Investigation

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Jiayi Hao,

Roles Methodology

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Xiaoshuang Shi,

Roles Investigation

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China
⨯
Dongliang Fei,

Roles Conceptualization

Affiliation College of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou, China
⨯
Mingxiao Ma ,

Roles Supervision, Writing – review & editing

* E-mail: lichang78@163.com (CL); qing@jlu.edu.cn (GW); lnjzmmx@163.com (MM)

Affiliation College of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou, China
⨯
Guoqing Wang ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: lichang78@163.com (CL); qing@jlu.edu.cn (GW); lnjzmmx@163.com (MM)

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China
⨯
Chang Li

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: lichang78@163.com (CL); qing@jlu.edu.cn (GW); lnjzmmx@163.com (MM)

Affiliation Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China

https://orcid.org/0000-0002-1386-4858

⨯

Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1

Jing Chen,
Peiheng Li,
Letian Li,
Ju Li,
Yuhang Jiang,
Wancheng Zou,
Pengfei Hao,
Zihan Gao,
Jiayi Hao,
Xiaoshuang Shi

Published: September 8, 2025
https://doi.org/10.1371/journal.ppat.1013495

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