Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus

Yuan Sun; Xiaoyang Shu; Lu Chen; Weijuan Shang; Yumin Zhang; Gengfu Xiao; Leike Zhang

doi:10.1371/journal.ppat.1013492

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Open Access

Peer-reviewed

Research Article

Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus

Yuan Sun ,

Contributed equally to this work with: Yuan Sun, Xiaoyang Shu

Roles Conceptualization, Data curation, Formal analysis, Project administration, Writing – original draft

Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Xiaoyang Shu ,

Contributed equally to this work with: Yuan Sun, Xiaoyang Shu

Roles Data curation, Formal analysis, Validation

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
⨯
Lu Chen,

Roles Data curation

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
⨯
Weijuan Shang,

Roles Data curation

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
⨯
Yumin Zhang ,

Roles Formal analysis, Methodology, Writing – review & editing

* E-mail: ymzhang@wh.iov.cn (YZ); xiaogf@wh.iov.cn (GX); zhangleike@wh.iov.cn (LZ)

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

https://orcid.org/0000-0003-0767-1221

⨯
Gengfu Xiao ,

Roles Methodology, Resources, Supervision, Writing – review & editing

* E-mail: ymzhang@wh.iov.cn (YZ); xiaogf@wh.iov.cn (GX); zhangleike@wh.iov.cn (LZ)

Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Leike Zhang

Roles Conceptualization, Resources, Supervision, Writing – review & editing

* E-mail: ymzhang@wh.iov.cn (YZ); xiaogf@wh.iov.cn (GX); zhangleike@wh.iov.cn (LZ)

Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, Hubei Jiangxia Laboratory, Wuhan, China
⨯

Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus

Yuan Sun,
Xiaoyang Shu,
Lu Chen,
Weijuan Shang,
Yumin Zhang,
Gengfu Xiao,
Leike Zhang

Published: September 8, 2025
https://doi.org/10.1371/journal.ppat.1013492

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