Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity

• Xinyu Wu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Shane M. Devine,

  Roles Project administration, Writing – review & editing

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Margareta Go,

  Roles Resources, Writing – review & editing

  Affiliation The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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• Julie V. Nguyen,

  Roles Resources, Writing – review & editing

  Affiliation The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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• Bernadine G. C. Lu,

  Roles Resources

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Katie Loi,

  Roles Resources

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Nathan W. Kuchel,

  Roles Resources

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Kym N. Lowes,

  Roles Resources

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Jeffrey P. Mitchell,

  Roles Resources

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Guillaume Lessene,

  Roles Funding acquisition, Writing – review & editing

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Victoria, Australia

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• David Komander,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Matthew E. Call ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: mecall@wehi.edu.au (MEC); mjcall@wehi.edu.au (MJC)

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

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• Melissa J. Call

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: mecall@wehi.edu.au (MEC); mjcall@wehi.edu.au (MJC)

  Affiliations The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

  https://orcid.org/0000-0001-7684-5841

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