N460S in PB2 and I163T in nucleoprotein synergistically enhance the viral replication and pathogenicity of influenza B virus

• Yang Wang ,

  Contributed equally to this work with: Yang Wang, Yu Gao, Tianxin Ma

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panweiqi@gird.cn (WP); jeffyah@163.com (ZY); wang_yang@gzlab.ac.cn (YW)

  Affiliations State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou National Laboratory, Guangzhou, Guangdong, China, Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications, Faculty of Innovation Engineering, Macau University of Science and Technology, Macau, China

  https://orcid.org/0000-0002-6527-864X

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• Yu Gao ,

  Contributed equally to this work with: Yang Wang, Yu Gao, Tianxin Ma

  Roles Investigation, Methodology, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Tianxin Ma ,

  Contributed equally to this work with: Yang Wang, Yu Gao, Tianxin Ma

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Yuting Ye,

  Roles Data curation, Formal analysis, Visualization

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Chenyang Cao,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Binqian Zou,

  Roles Investigation, Visualization

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Sulan Ye,

  Roles Investigation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Qingsheng Huang,

  Roles Investigation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Chunguang Yang,

  Roles Data curation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Shengfeng Li,

  Roles Investigation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Lixi Liang,

  Roles Investigation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Hongxuan Zhou,

  Roles Investigation

  Affiliation State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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• Zhiqi Zeng,

  Roles Funding acquisition, Investigation

  Affiliations State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications, Faculty of Innovation Engineering, Macau University of Science and Technology, Macau, China

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• Zifeng Yang ,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  * E-mail: panweiqi@gird.cn (WP); jeffyah@163.com (ZY); wang_yang@gzlab.ac.cn (YW)

  Affiliations State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou National Laboratory, Guangzhou, Guangdong, China, Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications, Faculty of Innovation Engineering, Macau University of Science and Technology, Macau, China, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China

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• Weiqi Pan

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: panweiqi@gird.cn (WP); jeffyah@163.com (ZY); wang_yang@gzlab.ac.cn (YW)

  Affiliations State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications, Faculty of Innovation Engineering, Macau University of Science and Technology, Macau, China

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