Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580

• Naveen Kumar,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Present affiliation: Department of Biochemistry, Central University of Rajasthan, Rajasthan, India.

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Zonghui Ma ,

  Contributed equally to this work with: Zonghui Ma, Fuquan Long

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  ¶☯ These authors contribute equally.

  Affiliation Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Fuquan Long ,

  Contributed equally to this work with: Zonghui Ma, Fuquan Long

  Roles Formal analysis, Investigation, Methodology

  ¶☯ These authors contribute equally.

  Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Sexually Transmitted Disease, Center of Infectious Skin Disease, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China

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• Srinivasa Reddy Bonam,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India

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• Hsien-Tsung Lai,

  Roles Formal analysis, Methodology

  Affiliation Simmons Comprehensive Cancer Center, Department of Biochemistry, and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas United States of America

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• Shwu-Yuan Wu,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Simmons Comprehensive Cancer Center, Department of Biochemistry, and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas United States of America

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• Haiying Chen,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Nicholas C. Hazell,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Jiani Bei,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Xuefeng Liu,

  Roles Methodology, Resources

  Affiliation Department of Pathology, The Ohio State University College of Medicine, Columbus, Ohio, United States of America

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• Yeqing Chen,

  Roles Formal analysis, Methodology

  Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America

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• Zhi Wei,

  Roles Formal analysis, Methodology, Resources

  Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America

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• Cheng-Ming Chiang,

  Roles Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Simmons Comprehensive Cancer Center, Department of Biochemistry, and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas United States of America

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• Jia Zhou,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Haitao Hu

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  * E-mail: huht@im.ac.cn

  Current Address: Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

  Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America

  https://orcid.org/0000-0002-6964-2314

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