Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption

Romane Milcamps; Belén Lizcano-Perret; Fanny Wavreil; Marielle Lebrun; Chiara Aloise; Didier Vertommen; Gaëtan Herinckx; Frank J.M. van Kuppeveld; Catherine Sadzot; Thomas Michiels

doi:10.1371/journal.ppat.1013420

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Open Access

Peer-reviewed

Research Article

Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption

Romane Milcamps,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Université catholique de Louvain, de Duve Institute, Brussels, Belgium
⨯
Belén Lizcano-Perret,

Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

Present address: Belén Lizcano-Perret, Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

Affiliation Université catholique de Louvain, de Duve Institute, Brussels, Belgium
⨯
Fanny Wavreil,

Roles Investigation

Affiliation Université catholique de Louvain, de Duve Institute, Brussels, Belgium
⨯
Marielle Lebrun,

Roles Investigation, Visualization, Writing – review & editing

Affiliation ULiege, GIGA-Immunobiology, laboratory of Virology and Immunology, Liège, Belgium
⨯
Chiara Aloise,

Roles Resources

Affiliation Utrecht University, Section of Virology, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht, the Netherlands
⨯
Didier Vertommen,

Roles Formal analysis, Investigation

Affiliation MASSPROT platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Gaëtan Herinckx,

Roles Investigation

Affiliation MASSPROT platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Frank J.M. van Kuppeveld,

Roles Resources, Writing – review & editing

Affiliation Utrecht University, Section of Virology, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht, the Netherlands
⨯
Catherine Sadzot,

Roles Supervision

Affiliation ULiege, GIGA-Immunobiology, laboratory of Virology and Immunology, Liège, Belgium
⨯
Thomas Michiels

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: thomas.michiels@uclouvain.be

Affiliation Université catholique de Louvain, de Duve Institute, Brussels, Belgium

https://orcid.org/0000-0001-9615-8053

⨯

Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption

Romane Milcamps,
Belén Lizcano-Perret,
Fanny Wavreil,
Marielle Lebrun,
Chiara Aloise,
Didier Vertommen,
Gaëtan Herinckx,
Frank J.M. van Kuppeveld,
Catherine Sadzot,
Thomas Michiels

Published: December 17, 2025
https://doi.org/10.1371/journal.ppat.1013420

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