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Open Access
Peer-reviewed
Research Article
Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction
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Lianshun Zheng ,
Contributed equally to this work with: Lianshun Zheng, Shuai Fu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft
Affiliations State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Hainan Institute of Zhejiang University, Sanya, P.R. China
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Shuai Fu ,
Contributed equally to this work with: Lianshun Zheng, Shuai Fu
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation
Affiliations State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, China
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Ming Zeng,
Roles Investigation, Software
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Liyan Li,
Roles Investigation, Visualization
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Dan Wang,
Roles Investigation, Methodology
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Shibo Gao,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Yunge Zhang,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Cui Zhang,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Shifang Fei,
Roles Investigation
Affiliations State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Hainan Institute of Zhejiang University, Sanya, P.R. China
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Xuan Ye,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Lele Chen,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Qianhui Chen,
Roles Investigation
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Yaqin Wang,
Roles Resources
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Xueping Zhou,
Roles Resources
Affiliations State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China, State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, P.R. China
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Yan Xie ,
Roles Funding acquisition, Project administration, Resources
* E-mail: wujx@zju.edu.cn (JW); bolihu@zju.edu.cn (BH); xiey@zju.edu.cn (YX)
Affiliation State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
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Boli Hu ,
Roles Methodology, Project administration, Writing – review & editing
* E-mail: wujx@zju.edu.cn (JW); bolihu@zju.edu.cn (BH); xiey@zju.edu.cn (YX)
Affiliation MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, P.R. China
⨯ - [ ... ],
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Jianxiang Wu
Roles Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: wujx@zju.edu.cn (JW); bolihu@zju.edu.cn (BH); xiey@zju.edu.cn (YX)
Affiliations State Key Laboratory of Rice Biology and Breeding, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Hainan Institute of Zhejiang University, Sanya, P.R. China
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Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction
- Lianshun Zheng,
- Shuai Fu,
- Ming Zeng,
- Liyan Li,
- Dan Wang,
- Shibo Gao,
- Yunge Zhang,
- Cui Zhang,
- Shifang Fei,
- Xuan Ye
- Published: August 19, 2025
- https://doi.org/10.1371/journal.ppat.1013415