Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19

Heather Learnard; Jason Core; Heather Corkrey; Anthony Sciaudone; Jeffrey Rade; Hardy Kornfeld; Jennifer P. Wang; Jane E. Freedman; Kahraman Tanriverdi; Milka Koupenova

doi:10.1371/journal.ppat.1013413

Loading metrics

Open Access

Peer-reviewed

Research Article

Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19

Heather Learnard ,

Contributed equally to this work with: Heather Learnard, Jason Core

Roles Conceptualization, Data curation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Internal Medicine Program, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Jason Core ,

Contributed equally to this work with: Heather Learnard, Jason Core

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Heather Corkrey,

Roles Data curation, Investigation, Writing – review & editing

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Internal Medicine Program, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Anthony Sciaudone,

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Internal Medicine Program, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Jeffrey Rade,

Roles Investigation, Writing – review & editing

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Internal Medicine Program, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Hardy Kornfeld,

Roles Conceptualization, Writing – review & editing

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Jennifer P. Wang,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Division of Infectious Diseases and Immunology and Diabetes Center of Excellence, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Jane E. Freedman,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, Tennessee, United States of America
⨯
Kahraman Tanriverdi,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, Tennessee, United States of America
⨯
Milka Koupenova

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Milka.Koupenova@umassmed.edu

Affiliations Department of Medicine, Divisions of Cardiovascular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Internal Medicine Program, UMass Chan Medical School, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0001-5934-8990

⨯

Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19

Heather Learnard,
Jason Core,
Heather Corkrey,
Anthony Sciaudone,
Jeffrey Rade,
Hardy Kornfeld,
Jennifer P. Wang,
Jane E. Freedman,
Kahraman Tanriverdi,
Milka Koupenova

Published: August 18, 2025
https://doi.org/10.1371/journal.ppat.1013413

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Platelets
Is the Subject Area "Platelets" applicable to this article?

Thanks for your feedback.
White blood cells
Is the Subject Area "White blood cells" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Toll-like receptors
Is the Subject Area "Toll-like receptors" applicable to this article?

Thanks for your feedback.
Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.
Thrombosis
Is the Subject Area "Thrombosis" applicable to this article?

Thanks for your feedback.
Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.