A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation

• Xiangyu Zhou ,

  Contributed equally to this work with: Xiangyu Zhou, Qingkai Xue

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China

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• Qingkai Xue ,

  Contributed equally to this work with: Xiangyu Zhou, Qingkai Xue

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Software, Writing – review & editing

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China, Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, PR China

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• Chengwei Wu,

  Roles Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China

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• Xiaojing Li,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, PR China

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• Yuyan Wang,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, PR China

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• Yang Dai,

  Roles Formal analysis, Methodology

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China

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• Chunrong Xiong,

  Roles Methodology, Software

  Affiliation National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China

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• Ying Zhang,

  Roles Investigation, Methodology

  Affiliation National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China

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• Yongliang Xu,

  Roles Investigation, Methodology

  Affiliation National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China

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• Xinjian Liu ,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  * E-mail: huangyuzheng@jipd.com (YH); liuxinjian@njmu.edu.cn (XL)

  Affiliation Department of Pathogen Biology, Key Laboratory of Antibody Techniques of National Health Commission, Nanjing Medical University, Nanjing, Jiangsu, PR China

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• Yuzheng Huang

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: huangyuzheng@jipd.com (YH); liuxinjian@njmu.edu.cn (XL)

  Affiliations National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China, Tropical Diseases Research Center, Nanjing Medical University, Wuxi, Jiangsu, PR China, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, PR China

  https://orcid.org/0000-0002-8357-8806

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