Age-associated immune dysregulation and B cell dysfunction drive severe outcomes in SFTSV infection

• Eun-Ha Kim ,

  Contributed equally to this work with: Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim, Dongbin Park

  Roles Data curation, Investigation, Resources

  Affiliation Center for Virus Research Resource, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

  ⨯
• Ho Bin Jang ,

  Contributed equally to this work with: Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim, Dongbin Park

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

  ⨯
• Se-Mi Kim ,

  Contributed equally to this work with: Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim, Dongbin Park

  Roles Data curation, Investigation, Resources

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Dongbin Park ,

  Contributed equally to this work with: Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim, Dongbin Park

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Young-Il Kim,

  Roles Investigation, Resources

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Seung-Gyu Jang,

  Roles Data curation

  Affiliations Center for Virus Research Resource, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

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• Suhee Hwang,

  Roles Methodology, Software

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Woo-Hyun Kwon,

  Roles Methodology, Software

  Affiliations Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

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• Isaac Choi,

  Roles Investigation, Resources

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Jaemoo Kim,

  Roles Investigation, Resources

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Hee-Dong Yang,

  Roles Methodology, Software, Visualization

  Affiliations Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

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• Hyunjoon Kim,

  Roles Writing – review & editing

  Affiliation Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

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• Mark Anthony B. Casel,

  Roles Writing – review & editing

  Affiliations Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

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• Min-Suk Song,

  Roles Conceptualization

  Affiliation Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

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• Jae U. Jung,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Cancer Biology, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Ohio, United States of America

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•  [ ... ],
• Young Ki Choi

  Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: choiki55@ibs.re.kr

  Affiliations Center for Virus Research Resource, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea, Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea, Lead contact

  https://orcid.org/0000-0002-0872-0147

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