Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Alexandra Wilson; Wael Kamel; Kelsey Davies; Zaydah R. De Laurent; Rozeena Arif; Andrew T. Clarke; Lesley Bell-Sakyi; Douglas Lamont; Yana Demyanenko; Marko Noerenberg; Alain Kohl; Shabaz Mohammed; Alfredo Castello; Benjamin Brennan

doi:10.1371/journal.ppat.1013393

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Open Access

Peer-reviewed

Research Article

Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Alexandra Wilson ,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

¶‡ joint first authors

Affiliations Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Wael Kamel ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

¶‡ joint first authors

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Kelsey Davies,

Roles Investigation, Resources, Writing – review & editing

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Zaydah R. De Laurent,

Roles Formal analysis, Methodology, Visualization

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Rozeena Arif,

Roles Formal analysis, Methodology, Visualization

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Andrew T. Clarke,

Roles Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Lesley Bell-Sakyi,

Roles Resources, Writing – review & editing

Affiliation Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom
⨯
Douglas Lamont,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation FingerPrints Proteomics Facility, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Yana Demyanenko,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford, Oxfordshire, United Kingdom
⨯
Marko Noerenberg,

Roles Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Alain Kohl,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom, Departments of Tropical Disease Biology and Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Shabaz Mohammed,

Roles Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford, Oxfordshire, United Kingdom, Department of Chemistry, University of Oxford, Oxford, United Kingdom, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Alfredo Castello ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ben.brennan@glasgow.ac.uk (BB); alfredo.castello@glasgow.ac.uk (AC)

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
⨯
Benjamin Brennan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ben.brennan@glasgow.ac.uk (BB); alfredo.castello@glasgow.ac.uk (AC)

Affiliation Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom

https://orcid.org/0000-0003-4707-726X

⨯

Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Alexandra Wilson,
Wael Kamel,
Kelsey Davies,
Zaydah R. De Laurent,
Rozeena Arif,
Andrew T. Clarke,
Lesley Bell-Sakyi,
Douglas Lamont,
Yana Demyanenko,
Marko Noerenberg

Published: August 4, 2025
https://doi.org/10.1371/journal.ppat.1013393

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Transfection
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RNA-binding proteins
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Immunoprecipitation
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Ticks
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Viral replication
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Virions
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Protein folding
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Cell cultures
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