Screening of different species reveals cat hepatocytes support HBV infection

Zaichao Xu; Kaitao Zhao; Jingjing Wang; Lu Zhang; Jiatong Yin; Nijing Chen; Sijia Chen; Gaihong Zhao; Mengfei Wang; Tailai Xin; Chengliang Zhu; Xiaoming Cheng; Yuchen Xia

doi:10.1371/journal.ppat.1013390

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Open Access

Peer-reviewed

Research Article

Screening of different species reveals cat hepatocytes support HBV infection

Zaichao Xu,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Kaitao Zhao,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Jingjing Wang,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Lu Zhang,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Jiatong Yin,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Nijing Chen,

Roles Investigation

Affiliations State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, Department of Pathology, Center for Pathology and Molecular Diagnostics, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital of Wuhan University, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Sijia Chen,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Gaihong Zhao,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Mengfei Wang,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Tailai Xin,

Roles Investigation

Affiliation State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Chengliang Zhu,

Roles Resources

Affiliation Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
⨯
Xiaoming Cheng ,

Roles Resources, Supervision

* E-mail: xiaoming.cheng@whu.edu.cn (XC); yuchenxia@whu.edu.cn (YX)

Affiliations State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, Department of Pathology, Center for Pathology and Molecular Diagnostics, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital of Wuhan University, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Yuchen Xia

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: xiaoming.cheng@whu.edu.cn (XC); yuchenxia@whu.edu.cn (YX)

Affiliations State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, Pingyuan Laboratory, Henan, China

https://orcid.org/0000-0001-8460-3893

⨯

Screening of different species reveals cat hepatocytes support HBV infection

Zaichao Xu,
Kaitao Zhao,
Jingjing Wang,
Lu Zhang,
Jiatong Yin,
Nijing Chen,
Sijia Chen,
Gaihong Zhao,
Mengfei Wang,
Tailai Xin

Published: August 4, 2025
https://doi.org/10.1371/journal.ppat.1013390

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