Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation

Shanshan Chen; Tongxue Qin; Shengrui Luo; Fengyi Wang; Feirong Chen; Hailun Wei; Yuting Wu; Rongfeng Chen; Wudi Wei; Jingzhen Lai; Hao Liang; Li Ye; Zongxiang Yuan; Junjun Jiang

doi:10.1371/journal.ppat.1013366

Loading metrics

Open Access

Review articles synthesize the best available evidence on a topic relevant to the pathogens community.

See all article types »

Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation

Shanshan Chen ,

Contributed equally to this work with: Shanshan Chen, Tongxue Qin, Shengrui Luo

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Tongxue Qin ,

Contributed equally to this work with: Shanshan Chen, Tongxue Qin, Shengrui Luo

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Shengrui Luo ,

Contributed equally to this work with: Shanshan Chen, Tongxue Qin, Shengrui Luo

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Fengyi Wang,

Roles Software, Validation

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Feirong Chen,

Roles Software, Validation

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Hailun Wei,

Roles Software, Validation

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Yuting Wu,

Roles Data curation

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Rongfeng Chen,

Roles Data curation

Affiliation Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Wudi Wei,

Roles Data curation

Affiliation Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Jingzhen Lai,

Roles Data curation

Affiliation Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Hao Liang ,

Roles Conceptualization, Project administration, Supervision

* E-mail: lianghao@gxmu.edu.cn (HL); yeli@gxmu.edu.cn (LY); yuanzongxiang@stu.gxmu.edu.cn (ZY); jiangjunjun@gxmu.edu.cn (JJ)

Affiliations Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China, Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Li Ye ,

Roles Conceptualization, Project administration, Supervision

* E-mail: lianghao@gxmu.edu.cn (HL); yeli@gxmu.edu.cn (LY); yuanzongxiang@stu.gxmu.edu.cn (ZY); jiangjunjun@gxmu.edu.cn (JJ)

Affiliations Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China, Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China
⨯
Zongxiang Yuan ,

Roles Conceptualization, Project administration, Supervision

* E-mail: lianghao@gxmu.edu.cn (HL); yeli@gxmu.edu.cn (LY); yuanzongxiang@stu.gxmu.edu.cn (ZY); jiangjunjun@gxmu.edu.cn (JJ)

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
⨯
Junjun Jiang

Roles Conceptualization, Project administration, Supervision

* E-mail: lianghao@gxmu.edu.cn (HL); yeli@gxmu.edu.cn (LY); yuanzongxiang@stu.gxmu.edu.cn (ZY); jiangjunjun@gxmu.edu.cn (JJ)

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China

https://orcid.org/0000-0003-4905-9348

⨯

Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation

Shanshan Chen,
Tongxue Qin,
Shengrui Luo,
Fengyi Wang,
Feirong Chen,
Hailun Wei,
Yuting Wu,
Rongfeng Chen,
Wudi Wei,
Jingzhen Lai

Published: July 28, 2025
https://doi.org/10.1371/journal.ppat.1013366

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Glycolysis
Is the Subject Area "Glycolysis" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Histones
Is the Subject Area "Histones" applicable to this article?

Thanks for your feedback.
Protein metabolism
Is the Subject Area "Protein metabolism" applicable to this article?

Thanks for your feedback.
Cell metabolism
Is the Subject Area "Cell metabolism" applicable to this article?

Thanks for your feedback.
Viral transmission and infection
Is the Subject Area "Viral transmission and infection" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Lysine
Is the Subject Area "Lysine" applicable to this article?

Thanks for your feedback.