Critical role of P-Glycoprotein-9 in ivermectin tolerance in nematodes

Clara Blancfuney; Eva Guchen; Marie Garcia; Julien Faccini; Jean-François Sutra; Felipe Ramon-Portugal; Elise Courtot; Marlène Z. Lacroix; Roger Prichard; Anne Lespine; Mélanie Alberich

doi:10.1371/journal.ppat.1013355

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Open Access

Peer-reviewed

Research Article

Critical role of P-Glycoprotein-9 in ivermectin tolerance in nematodes

Clara Blancfuney,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Eva Guchen,

Roles Investigation

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Marie Garcia,

Roles Investigation

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Julien Faccini,

Roles Investigation

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Jean-François Sutra,

Roles Investigation, Methodology

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Felipe Ramon-Portugal,

Roles Investigation

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Elise Courtot,

Roles Methodology, Writing – review & editing

Affiliation ISP, Université de Tours, INRAE, Nouzilly, France
⨯
Marlène Z. Lacroix,

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Roger Prichard,

Roles Writing – review & editing

Affiliation Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, Canada
⨯
Anne Lespine ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: melanie.alberich@inrae.fr (MA); anne.lespine@inrae.fr (AL)

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France

https://orcid.org/0000-0001-8153-8555

⨯
Mélanie Alberich

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: melanie.alberich@inrae.fr (MA); anne.lespine@inrae.fr (AL)

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France

https://orcid.org/0000-0001-6231-4230

⨯

Critical role of P-Glycoprotein-9 in ivermectin tolerance in nematodes

Clara Blancfuney,
Eva Guchen,
Marie Garcia,
Julien Faccini,
Jean-François Sutra,
Felipe Ramon-Portugal,
Elise Courtot,
Marlène Z. Lacroix,
Roger Prichard,
Anne Lespine

Published: March 23, 2026
https://doi.org/10.1371/journal.ppat.1013355

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RNA interference
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Larvae
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