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Open Access
Peer-reviewed
Research Article
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation
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Sisi Xia ,
Contributed equally to this work with: Sisi Xia, Xiaoping Huo
Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft
Affiliations Department of Biological Engineering, Wuhan Polytechnic University, Wuhan, China, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China
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Xiaoping Huo ,
Contributed equally to this work with: Sisi Xia, Xiaoping Huo
Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft
Affiliations State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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Nanfang Liu,
Roles Formal analysis, Investigation, Methodology, Validation
Affiliation Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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Xinyu Liu,
Roles Investigation, Methodology
Affiliation Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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Tianyou Wang,
Roles Investigation, Methodology
Affiliation Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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Muyi Guo,
Roles Investigation, Methodology
Affiliations State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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Chi Zeng ,
Roles Project administration, Resources, Writing – review & editing
* E-mail: chenjun@jnu.edu.cn (JC); wanpin@whu.edu.cn (PW); czeng@whpu.edu.cn (CZ)
Affiliation Department of Biological Engineering, Wuhan Polytechnic University, Wuhan, China
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Pin Wan ,
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: chenjun@jnu.edu.cn (JC); wanpin@whu.edu.cn (PW); czeng@whpu.edu.cn (CZ)
Affiliation Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China
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Jun Chen
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: chenjun@jnu.edu.cn (JC); wanpin@whu.edu.cn (PW); czeng@whpu.edu.cn (CZ)
Affiliations State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China
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SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation
- Sisi Xia,
- Xiaoping Huo,
- Nanfang Liu,
- Xinyu Liu,
- Tianyou Wang,
- Muyi Guo,
- Chi Zeng,
- Pin Wan,
- Jun Chen
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- Published: July 16, 2025
- https://doi.org/10.1371/journal.ppat.1013344