Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females

Lydia Labrie; Rojine C. McVea; Rami Karkout; Haya Aldossary; Véronique Gaudreault; Brian J. Ward; Elizabeth D. Fixman

doi:10.1371/journal.ppat.1013340

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Open Access

Peer-reviewed

Research Article

Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females

Lydia Labrie ,

Contributed equally to this work with: Lydia Labrie, Rojine C. McVea

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Rojine C. McVea ,

Contributed equally to this work with: Lydia Labrie, Rojine C. McVea

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Rami Karkout,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Haya Aldossary,

Roles Data curation, Writing – review & editing

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Véronique Gaudreault,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Brian J. Ward,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Research Institute of the McGill University Health Centre, Montréal, Québec, Canada
⨯
Elizabeth D. Fixman

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: elizabeth.fixman@mcgill.ca

Affiliation Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada

https://orcid.org/0000-0002-6177-8794

⨯

Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females

Lydia Labrie,
Rojine C. McVea,
Rami Karkout,
Haya Aldossary,
Véronique Gaudreault,
Brian J. Ward,
Elizabeth D. Fixman

Published: July 21, 2025
https://doi.org/10.1371/journal.ppat.1013340

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