Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi

• Joshua W. McCausland ,

  Contributed equally to this work with: Joshua W. McCausland, Zachary A. Kloos, Irnov Irnov, Nicole D. Sonnert

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Sarafan ChEM-H Institute, Stanford University, Stanford, California, United States of America, Department of Biology, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America

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• Zachary A. Kloos ,

  Contributed equally to this work with: Joshua W. McCausland, Zachary A. Kloos, Irnov Irnov, Nicole D. Sonnert

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Microbiology Program, Yale University, New Haven, Connecticut, United States of America

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• Irnov Irnov ,

  Contributed equally to this work with: Joshua W. McCausland, Zachary A. Kloos, Irnov Irnov, Nicole D. Sonnert

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Sarafan ChEM-H Institute, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America

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• Nicole D. Sonnert ,

  Contributed equally to this work with: Joshua W. McCausland, Zachary A. Kloos, Irnov Irnov, Nicole D. Sonnert

  Roles Investigation, Writing – review & editing

  Affiliations Microbiology Program, Yale University, New Haven, Connecticut, United States of America, Department of Immunology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Junhui Zhou,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America

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• Rachel Putnik,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America

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• Elizabeth A. Mueller,

  Roles Investigation, Writing – review & editing

  Affiliations Sarafan ChEM-H Institute, Stanford University, Stanford, California, United States of America, Department of Biology, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America

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• Allen C. Steere,

  Roles Resources, Writing – review & editing

  Affiliation Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Noah W. Palm,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Immunology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Catherine L. Grimes,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, United States of America

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• Christine Jacobs-Wagner

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jacobs-wagner@stanford.edu

  Affiliations Sarafan ChEM-H Institute, Stanford University, Stanford, California, United States of America, Department of Biology, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

  https://orcid.org/0000-0003-0980-5334

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