Nutrient stress dramatically increases malaria parasite clag2 copy number to increase host cell permeability and enable pathogen survival

Nicole B. Potchen; Tatiane Macedo Silva; Inderjeet Kalia; Justin B. Lack; Sanjay A. Desai

doi:10.1371/journal.ppat.1013321

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Peer-reviewed

Research Article

Nutrient stress dramatically increases malaria parasite clag2 copy number to increase host cell permeability and enable pathogen survival

Nicole B. Potchen ,

Contributed equally to this work with: Nicole B. Potchen, Tatiane Macedo Silva, Inderjeet Kalia

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Current Address: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Tatiane Macedo Silva ,

Contributed equally to this work with: Nicole B. Potchen, Tatiane Macedo Silva, Inderjeet Kalia

Roles Investigation, Writing – review & editing

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Inderjeet Kalia ,

Contributed equally to this work with: Nicole B. Potchen, Tatiane Macedo Silva, Inderjeet Kalia

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Justin B. Lack,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Integrated Data Sciences Section, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Sanjay A. Desai

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sdesai@niaid.nih.gov

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Rockville, Maryland, United States of America

https://orcid.org/0000-0003-2150-2483

⨯

Nutrient stress dramatically increases malaria parasite clag2 copy number to increase host cell permeability and enable pathogen survival

Nicole B. Potchen,
Tatiane Macedo Silva,
Inderjeet Kalia,
Justin B. Lack,
Sanjay A. Desai

Published: October 16, 2025
https://doi.org/10.1371/journal.ppat.1013321

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Permeability
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Parasitic diseases
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Plasmodium
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Malarial parasites
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Cytolysis
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Parasite replication
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Polymerase chain reaction
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