Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis

Riya Ghosh; Garima Joshi; Nishith M. Shrimali; Kanchan Bhardwaj; Tsewang Chorol; Tashi Thinlas; Parvaiz A. Koul; Josef T. Prchal; Prasenjit Guchhait

doi:10.1371/journal.ppat.1013296

Loading metrics

Open Access

Peer-reviewed

Research Article

Tibetan PHD2^D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis

Riya Ghosh,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Manav Rachna International Institute of Research and Studies, Faridabad, India, Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India
⨯
Garima Joshi,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India
⨯
Nishith M. Shrimali,

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliation Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India
⨯
Kanchan Bhardwaj,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Manav Rachna International Institute of Research and Studies, Faridabad, India, Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India
⨯
Tsewang Chorol,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Sonam Nurboo Memorial Hospital, Leh-Ladakh, Jammu and Kashmir, India
⨯
Tashi Thinlas,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Sonam Nurboo Memorial Hospital, Leh-Ladakh, Jammu and Kashmir, India
⨯
Parvaiz A. Koul,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Internal and Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India
⨯
Josef T. Prchal,

Roles Conceptualization, Writing – original draft

Affiliation Department of Medicine, University of Utah School of Medicine & Huntsman Cancer Center and George E. Wahlin Veteran’s Administration Medical Center, Salt Lake City, Utah, United States of America
⨯
Prasenjit Guchhait

Roles Conceptualization, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: prasenjit@rcb.res.in

Affiliation Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India

https://orcid.org/0000-0002-6601-6692

⨯

Tibetan PHD2^D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis

Riya Ghosh,
Garima Joshi,
Nishith M. Shrimali,
Kanchan Bhardwaj,
Tsewang Chorol,
Tashi Thinlas,
Parvaiz A. Koul,
Josef T. Prchal,
Prasenjit Guchhait

Published: June 26, 2025
https://doi.org/10.1371/journal.ppat.1013296

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Tibetan people
Is the Subject Area "Tibetan people" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Medical hypoxia
Is the Subject Area "Medical hypoxia" applicable to this article?

Thanks for your feedback.
Analysis of variance
Is the Subject Area "Analysis of variance" applicable to this article?

Thanks for your feedback.
Viral transmission and infection
Is the Subject Area "Viral transmission and infection" applicable to this article?

Thanks for your feedback.
COVID 19
Is the Subject Area "COVID 19" applicable to this article?

Thanks for your feedback.
SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.