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Open Access
Peer-reviewed
Research Article
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
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Jianchao Zhang ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: jczha@umich.edu (JZ); andrewwt@med.umich.edu (AWT); yzwang@szbl.ac.cn (YW)
Affiliations Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
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Andrew Kennedy ,
Contributed equally to this work with: Andrew Kennedy, Daniel Macedo de Melo Jorge, Lijuan Xing
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Daniel Macedo de Melo Jorge ,
Contributed equally to this work with: Andrew Kennedy, Daniel Macedo de Melo Jorge, Lijuan Xing
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Lijuan Xing ,
Contributed equally to this work with: Andrew Kennedy, Daniel Macedo de Melo Jorge, Lijuan Xing
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Whitney Reid,
Roles Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Sarah Bui,
Roles Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Joseph Joppich,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Molly Rose,
Roles Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Sevval Ercan,
Roles Investigation, Writing – review & editing
Affiliation Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Qiyi Tang,
Roles Resources, Writing – review & editing
Affiliation Department of Microbiology, Howard University College of Medicine, Washington, DC, United States of America
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David Ginsburg,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Departmentof Internal Medicine, Human Genetics, and Pediatrics, University of Michigan, Ann Arbor, Michigan, United States of America
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Andrew W. Tai ,
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jczha@umich.edu (JZ); andrewwt@med.umich.edu (AWT); yzwang@szbl.ac.cn (YW)
Affiliations Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Yanzhuang Wang
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jczha@umich.edu (JZ); andrewwt@med.umich.edu (AWT); yzwang@szbl.ac.cn (YW)
Affiliations Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China
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SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
- Jianchao Zhang,
- Andrew Kennedy,
- Daniel Macedo de Melo Jorge,
- Lijuan Xing,
- Whitney Reid,
- Sarah Bui,
- Joseph Joppich,
- Molly Rose,
- Sevval Ercan,
- Qiyi Tang
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- Published: June 20, 2025
- https://doi.org/10.1371/journal.ppat.1013295
- See the preprint