Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection

Lonneke V. Nouwen; Esther A. Zaal; Inge Buitendijk; Marleen Zwaagstra; Chiara Aloise; Arno L. W. van Vliet; Jelle G. Schipper; Alain van Mil; Celia R. Berkers; Frank J. M. van Kuppeveld

doi:10.1371/journal.ppat.1013293

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Open Access

Peer-reviewed

Research Article

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection

Lonneke V. Nouwen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Esther A. Zaal,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Division Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Inge Buitendijk,

Roles Investigation, Methodology

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Marleen Zwaagstra,

Roles Investigation, Methodology

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Chiara Aloise,

Roles Investigation, Methodology

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Arno L. W. van Vliet,

Roles Investigation, Methodology

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Jelle G. Schipper,

Roles Investigation, Methodology

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Alain van Mil,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Visualization

Affiliation Experimental Cardiology Laboratory, Department of Cardiology, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
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Celia R. Berkers ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: F.J.M.vanKuppeveld@uu.nl (FJMK); C.R.Berkers@uu.nl (CRB)

Affiliation Division Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Frank J. M. van Kuppeveld

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: F.J.M.vanKuppeveld@uu.nl (FJMK); C.R.Berkers@uu.nl (CRB)

Affiliation Section of Virology, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0001-5800-749X

⨯

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection

Lonneke V. Nouwen,
Esther A. Zaal,
Inge Buitendijk,
Marleen Zwaagstra,
Chiara Aloise,
Arno L. W. van Vliet,
Jelle G. Schipper,
Alain van Mil,
Celia R. Berkers,
Frank J. M. van Kuppeveld

Published: July 3, 2025
https://doi.org/10.1371/journal.ppat.1013293

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