A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene

• Cristina Sampedro-Torres-Quevedo ,

  Contributed equally to this work with: Cristina Sampedro-Torres-Quevedo, Hasier Eraña

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain

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• Hasier Eraña ,

  Contributed equally to this work with: Cristina Sampedro-Torres-Quevedo, Hasier Eraña

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, ATLAS Molecular Pharma S. L., Derio, Spain

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• Jorge M. Charco,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, ATLAS Molecular Pharma S. L., Derio, Spain

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• Carlos M. Díaz-Domínguez,

  Roles Investigation, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain

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• Maitena San-Juan-Ansoleaga,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Eva Fernández-Muñoz,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Nuno Gonçalves-Anjo,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Josu Galarza-Ahumada,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Ana R. Cortazar,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Genome Analysis Platform, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Roberto F. Nespolo,

  Roles Investigation, Writing – review & editing

  Affiliations Instituto de Ciencias Ambientales y Evolutivas, Universidad Austral de Chile, Valdivia, Chile, Center of Applied Ecology and Sustainability (CAPES), Facultad de Ciencias Biológicas, Universidad Católica de Chile, Santiago, Chile, Millenium Institute for Integrative Biology (iBio), Santiago, Chile

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• Julian F. Quintero-Galvis,

  Roles Investigation, Writing – review & editing

  Affiliation Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez, Santiago, Chile

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• Africa Manero-Azua,

  Roles Investigation, Writing – review & editing

  Affiliation Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain

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• Diego Polanco-Alonso,

  Roles Investigation, Writing – review & editing

  Affiliation Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain

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• Adrián Gaite-Reguero,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Íñigo Olalde,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliations BIOMICs Research Group, Department of Zoology and Animal Cell Biology, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

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• Urko M. Marigorta,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

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• Guiomar Perez de Nanclares,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain

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• Ana M. Aransay,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Genome Analysis Platform, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain

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•  [ ... ],
• Joaquín Castilla

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jcastilla@cicbiogune.es

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Prion Lab and Integrative Genomics Lab, Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

  https://orcid.org/0000-0002-2216-1361

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