TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

Jingyu Zhou; Qingluan Yang; Haoxin Xu; Huaxin Chen; Ning Jiang; Qinfang Ou; Mengqing Qian; Xing Lin; Yixuan Yang; Feiran Zhou; Yuzhen Xu; Qianqian Liu; Yuanyuan Liu; Yan Gao; Wenhong Zhang; Lingyun Shao; Qiaoling Ruan

doi:10.1371/journal.ppat.1013228

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Open Access

Peer-reviewed

Research Article

TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

Jingyu Zhou ,

Contributed equally to this work with: Jingyu Zhou, Qingluan Yang, Haoxin Xu, Huaxin Chen

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Qingluan Yang ,

Contributed equally to this work with: Jingyu Zhou, Qingluan Yang, Haoxin Xu, Huaxin Chen

Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Haoxin Xu ,

Contributed equally to this work with: Jingyu Zhou, Qingluan Yang, Haoxin Xu, Huaxin Chen

Roles Investigation, Validation, Writing – review & editing

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Huaxin Chen ,

Contributed equally to this work with: Jingyu Zhou, Qingluan Yang, Haoxin Xu, Huaxin Chen

Roles Investigation, Resources

Affiliation Department of Pulmonary Diseases, Wuxi Fifth People′s Hospital, Wuxi, China
⨯
Ning Jiang,

Roles Data curation, Methodology, Software, Writing – review & editing

Affiliations Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China, Department of Biostatistics and Computational Biology, SKLG, School of Life Sciences, Fudan University, Shanghai, China, Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China
⨯
Qinfang Ou,

Roles Resources

Affiliation Department of Pulmonary Diseases, Wuxi Fifth People′s Hospital, Wuxi, China
⨯
Mengqing Qian,

Roles Investigation, Validation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Xing Lin,

Roles Investigation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Yixuan Yang,

Roles Investigation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Feiran Zhou,

Roles Investigation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Yuzhen Xu,

Roles Investigation, Validation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Qianqian Liu,

Roles Investigation, Methodology

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Yuanyuan Liu,

Roles Funding acquisition, Methodology

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Yan Gao,

Roles Methodology, Resources

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
Wenhong Zhang,

Roles Resources, Supervision

Affiliations Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China, Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China
⨯
Lingyun Shao ,

Roles Resources, Supervision, Writing – review & editing

* E-mail: lingyun26@fudan.edu.cn; (LS) qlruan07@fudan.edu.cn (QR)

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
⨯
[ ... ],
Qiaoling Ruan

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: lingyun26@fudan.edu.cn; (LS) qlruan07@fudan.edu.cn (QR)

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

https://orcid.org/0000-0003-4931-3510

⨯
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TIGIT blockade improves anti-Mycobacterium tuberculosis immunity

Jingyu Zhou,
Qingluan Yang,
Haoxin Xu,
Huaxin Chen,
Ning Jiang,
Qinfang Ou,
Mengqing Qian,
Xing Lin,
Yixuan Yang,
Feiran Zhou

Published: June 17, 2025
https://doi.org/10.1371/journal.ppat.1013228

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