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Open Access
Peer-reviewed
Research Article
The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii
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Jeanette M. Critchlow ,
Contributed equally to this work with: Jeanette M. Critchlow, Joseph S. Rocchio
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Joseph S. Rocchio ,
Contributed equally to this work with: Jeanette M. Critchlow, Joseph S. Rocchio
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America
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Melanie C. McKell,
Roles Data curation, Formal analysis
Affiliation Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Courtney J. Campbell,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, United States of America
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Juan P. Barraza,
Roles Formal analysis, Visualization
Affiliation Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Evan S. Krystofiak,
Roles Data curation, Visualization
Affiliation Department of Cell and Developmental Biology and Cell Imaging Shared Resource, Vanderbilt University, Nashville, Tennessee, United States of America
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Erin R. Green,
Roles Investigation, Methodology, Writing – review & editing
Affiliations Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Microbiology, University of Chicago, Chicago, Illinois, United States of America
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Tae Akizuki,
Roles Investigation
Affiliation Departments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America
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Walter J. Chazin,
Roles Funding acquisition, Investigation, Writing – review & editing
Affiliation Departments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America
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Michael S. VanNieuwenhze,
Roles Investigation
Affiliation Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America
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Timothy L. Stemmler,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, United States of America
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David P. Giedroc ,
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: eric.skaar@vumc.org (EPS); giedroc@iu.edu (DPG)
Affiliations Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America, Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, United States of America
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Eric P. Skaar
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing
* E-mail: eric.skaar@vumc.org (EPS); giedroc@iu.edu (DPG)
Affiliation Department of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii
- Jeanette M. Critchlow,
- Joseph S. Rocchio,
- Melanie C. McKell,
- Courtney J. Campbell,
- Juan P. Barraza,
- Evan S. Krystofiak,
- Erin R. Green,
- Tae Akizuki,
- Walter J. Chazin,
- Michael S. VanNieuwenhze
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- Published: June 16, 2025
- https://doi.org/10.1371/journal.ppat.1013209