The adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cells

• Madison Moore,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

  Affiliation Department of Biology, College of Arts and Sciences, Howard University, Washington, D.C., United States of America

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• Jiang Kong,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, School of Medicine, Howard University, Washington, D.C., United States of America

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• Ahlam Akmel,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biology, College of Arts and Sciences, Howard University, Washington, D.C., United States of America

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• Michael A. Thomas

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: michael.thomas1@howard.edu

  Affiliation Department of Biology, College of Arts and Sciences, Howard University, Washington, D.C., United States of America

  https://orcid.org/0000-0003-0134-8765

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