The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion

Xue-Mei Yi; Mi Li; Su-Yun Wang; Shi-Han Wang; Jia-Qing Zeng; Ya-Li Lei; Yu Zhang; Chun-Yu Zhu; Ying Zhang; Jun-Hui Song; Yun-Da Chen; Yun Wang; Hong-Bing Shu; Shu Li; Yan-Yi Wang

doi:10.1371/journal.ppat.1013198

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Open Access

Peer-reviewed

Research Article

The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion

Xue-Mei Yi ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

¶‡ These authors share first-authorship.

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Mi Li ,

Roles Formal analysis, Investigation

¶‡ These authors share first-authorship.

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Su-Yun Wang ,

Roles Investigation

¶‡ These authors share first-authorship.

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Shi-Han Wang,

Roles Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Jia-Qing Zeng,

Roles Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Ya-Li Lei,

Roles Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Yu Zhang,

Roles Investigation

Affiliation College of Life Science, Liaoning University, Shenyang, Liaoning, China
⨯
Chun-Yu Zhu,

Roles Formal analysis, Supervision

Affiliation College of Life Science, Liaoning University, Shenyang, Liaoning, China
⨯
Ying Zhang,

Roles Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Jun-Hui Song,

Roles Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Yun-Da Chen,

Roles Formal analysis, Investigation

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Yun Wang,

Roles Formal analysis, Investigation, Resources

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Hong-Bing Shu ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: shuh@whu.edu.cn (BS); shuli@whu.edu.cn (SL); wangyy@wh.iov.cn (Y-YW)

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China

https://orcid.org/0000-0001-9102-3272

⨯
Shu Li ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: shuh@whu.edu.cn (BS); shuli@whu.edu.cn (SL); wangyy@wh.iov.cn (Y-YW)

Affiliation Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Hubei Provincial Research Center for Basic Biological Sciences, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China
⨯
Yan-Yi Wang

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: shuh@whu.edu.cn (BS); shuli@whu.edu.cn (SL); wangyy@wh.iov.cn (Y-YW)

Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯

The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion

Xue-Mei Yi,
Mi Li,
Su-Yun Wang,
Shi-Han Wang,
Jia-Qing Zeng,
Ya-Li Lei,
Yu Zhang,
Chun-Yu Zhu,
Ying Zhang,
Jun-Hui Song

Published: June 11, 2025
https://doi.org/10.1371/journal.ppat.1013198

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