Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus

Huiyun Zhang; Shiyong Wang; Yu Zhang; Wenya Hua; Siran Lin; Xinchang Chen; Tao Xu; Jiazhen Chen; Wenhong Zhang

doi:10.1371/journal.ppat.1013190

Loading metrics

Open Access

Peer-reviewed

Research Article

Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus

Huiyun Zhang,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Shiyong Wang,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Yu Zhang,

Roles Investigation, Software, Visualization

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Wenya Hua,

Roles Methodology, Resources

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Siran Lin,

Roles Formal analysis, Validation

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Xinchang Chen,

Roles Data curation, Formal analysis, Funding acquisition

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Tao Xu,

Roles Methodology, Software

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China
⨯
Jiazhen Chen ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: jiazhen_chen@163.com

Affiliation Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China

https://orcid.org/0000-0001-8599-3766

⨯
Wenhong Zhang

Roles Conceptualization, Project administration, Supervision

Affiliations Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China, Shanghai Sci-Tech Inno Center for Infection & Immunity, Shanghai, China
⨯

Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus

Huiyun Zhang,
Shiyong Wang,
Yu Zhang,
Wenya Hua,
Siran Lin,
Xinchang Chen,
Tao Xu,
Jiazhen Chen,
Wenhong Zhang

Published: May 30, 2025
https://doi.org/10.1371/journal.ppat.1013190

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Insertion mutation
Is the Subject Area "Insertion mutation" applicable to this article?

Thanks for your feedback.
Regulator genes
Is the Subject Area "Regulator genes" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Electrophoretic mobility shift assay
Is the Subject Area "Electrophoretic mobility shift assay" applicable to this article?

Thanks for your feedback.
Operons
Is the Subject Area "Operons" applicable to this article?

Thanks for your feedback.
Hyperexpression techniques
Is the Subject Area "Hyperexpression techniques" applicable to this article?

Thanks for your feedback.
Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
RNA sequencing
Is the Subject Area "RNA sequencing" applicable to this article?

Thanks for your feedback.