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Open Access
Peer-reviewed
Research Article
EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1
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Ru Gao,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft
Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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Heping Wang,
Roles Data curation
Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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Zhihui Cui,
Roles Data curation
Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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Yanyun Du,
Roles Formal analysis, Funding acquisition
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China, Key Laboratory of Personalized Medicine Research and Treatment of Sichuan Province, Sichuan Provincial People’s Hospital, Chengdu, China
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Ruirui He,
Roles Formal analysis, Funding acquisition
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China, Key Laboratory of Personalized Medicine Research and Treatment of Sichuan Province, Sichuan Provincial People’s Hospital, Chengdu, China
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Lingyun Feng,
Roles Formal analysis, Funding acquisition
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Bo Zeng,
Roles Formal analysis, Funding acquisition, Methodology, Software, Validation
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Yangyang Li,
Roles Funding acquisition, Investigation, Methodology
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Guoling Huang,
Roles Investigation
Affiliation School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Ting Pan,
Roles Investigation
Affiliation School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Yuan Wang,
Roles Investigation
Affiliation School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Ming Yi ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: yimingemail1234@uestc.edu.cn (MY); wangch@uestc.edu.cn (CW)
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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Chenhui Wang
Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: yimingemail1234@uestc.edu.cn (MY); wangch@uestc.edu.cn (CW)
Affiliations The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China, Sichuan Medical Laboratory Clinical Medical Research Center, Sichuan Provincial People’s Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China, Key Laboratory of Personalized Medicine Research and Treatment of Sichuan Province, Sichuan Provincial People’s Hospital, Chengdu, China
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EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1
- Ru Gao,
- Heping Wang,
- Zhihui Cui,
- Yanyun Du,
- Ruirui He,
- Lingyun Feng,
- Bo Zeng,
- Yangyang Li,
- Guoling Huang,
- Ting Pan
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- Published: June 9, 2025
- https://doi.org/10.1371/journal.ppat.1013179