Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection

Chaminda D. Gunawardene; Isha Pandey; Shruti Chatterjee; Yoatzin Peñaflor-Téllez; Abby Odle; Abbey N. Warren; Adriana Messyasz; Ricardo Rajsbaum; Alan Sariol; Lok-Yin Roy Wong

doi:10.1371/journal.ppat.1013148

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Open Access

Peer-reviewed

Research Article

Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection

Chaminda D. Gunawardene,

Roles Conceptualization, Data curation, Investigation

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Isha Pandey,

Roles Data curation, Formal analysis, Investigation

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Shruti Chatterjee,

Roles Data curation, Investigation

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Yoatzin Peñaflor-Téllez,

Roles Data curation, Investigation, Writing – review & editing

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Abby Odle,

Roles Data curation, Investigation

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Abbey N. Warren,

Roles Data curation, Investigation

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
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Adriana Messyasz,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Molecular and Genomics Informatics Core Facility, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Ricardo Rajsbaum,

Roles Conceptualization

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Alan Sariol,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Lok-Yin Roy Wong

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: roy.wong@rutgers.edu

Affiliations Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America

https://orcid.org/0000-0002-0727-8289

⨯

Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection

Chaminda D. Gunawardene,
Isha Pandey,
Shruti Chatterjee,
Yoatzin Peñaflor-Téllez,
Abby Odle,
Abbey N. Warren,
Adriana Messyasz,
Ricardo Rajsbaum,
Alan Sariol,
Lok-Yin Roy Wong

Published: December 5, 2025
https://doi.org/10.1371/journal.ppat.1013148

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