Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

• Monnette F. Summers,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, School of Medicine and Public health, Madison, Wisconsin, United States of America

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• MegAnn K. Haubold,

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliation McArdle Laboratory for Cancer Research, School of Medicine and Public health, Madison, Wisconsin, United States of America

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• Marcel Morgenstern,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliations Department of Biomolecular Chemistry, School of Medicine and Public health, Madison, Wisconsin, United States of America, National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Phoenix Shepherd,

  Roles Investigation, Methodology

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Clairine I. S. Larsen,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, School of Medicine and Public health, Madison, Wisconsin, United States of America

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• Ava E. Bartz,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, School of Medicine and Public health, Madison, Wisconsin, United States of America

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• Gopishankar Thirumoorthy,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, Madison, Wisconsin United States of America

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• Robert N. Kirchdoerfer,

  Roles Project administration, Supervision

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Joshua J. Coon,

  Roles Conceptualization, Project administration, Resources, Software, Supervision

  Affiliations Department of Biomolecular Chemistry, School of Medicine and Public health, Madison, Wisconsin, United States of America, National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Morgridge Institute for Research, Madison, Wisconsin, United States of America

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• Kavi P. M. Mehta,

  Roles Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Comparative Biosciences, School of Veterinary Medicine, Madison, Wisconsin United States of America, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America

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• Kinjal Majumder

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kmajumder@wisc.edu

  Affiliations Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, McArdle Laboratory for Cancer Research, School of Medicine and Public health, Madison, Wisconsin, United States of America, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0002-1898-8251

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