Vacuolar sterol β-glucosidase EGCrP2/Sgl1 deficiency in Cryptococcus neoformans: Dysfunctional autophagy and Mincle-dependent immune activation as targets of novel antifungal strategies

• Takashi Watanabe ,

  Contributed equally to this work with: Takashi Watanabe, Masayoshi Nagai, Yohei Ishibashi

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, Department of Pathophysiology and Metabolism, Kawasaki Medical School, Kurashiki, Japan

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• Masayoshi Nagai ,

  Contributed equally to this work with: Takashi Watanabe, Masayoshi Nagai, Yohei Ishibashi

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan

  ⨯
• Yohei Ishibashi ,

  Contributed equally to this work with: Takashi Watanabe, Masayoshi Nagai, Yohei Ishibashi

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: makotoi@agr.kyushu-u.ac.jp (MI); ishibashiyo@agr.kyushu-u.ac.jp (YI)

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

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• Mio Iwasaki,

  Roles Investigation

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

  ⨯
• Masaki Mizoguchi,

  Roles Investigation

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

  ⨯
• Masahiro Nagata,

  Roles Investigation

  Affiliation Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

  ⨯
• Takashi Imai,

  Roles Investigation

  Affiliation Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

  ⨯
• Koichi Takato,

  Roles Investigation

  Affiliation Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan

  ⨯
• Akihiro Imamura,

  Roles Investigation

  Affiliations Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan, Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan

  ⨯
• Yoshimitsu Kakuta,

  Roles Investigation, Writing – original draft

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

  ⨯
• Takamasa Teramoto,

  Roles Investigation

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

  ⨯
• Motohiro Tani,

  Roles Resources

  Affiliations Department of Chemistry, Faculty of Science, Kyushu University, Fukuoka, Japan, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan

  ⨯
• Junko Matsuda,

  Roles Investigation

  Affiliation Department of Pathophysiology and Metabolism, Kawasaki Medical School, Kurashiki, Japan

  ⨯
• Hideharu Ishida,

  Roles Resources

  Affiliations Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan, Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan

  ⨯
• Sho Yamasaki,

  Roles Funding acquisition, Resources

  Affiliations Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan

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• Nozomu Okino,

  Roles Validation

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

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•  [ ... ],
• Makoto Ito

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: makotoi@agr.kyushu-u.ac.jp (MI); ishibashiyo@agr.kyushu-u.ac.jp (YI)

  Affiliation Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

  https://orcid.org/0000-0003-3159-7818

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