Human monoclonal antibodies to HPV16 show evidence for common developmental pathways and public epitopes

Joseph J. Carter; Nicholas K. Hurlburt; Erin M. Scherer; Suruchi Singh; Justas V. Rodarte; Robin A. Smith; Peter Lewis; Rachel Kinzelman; Jacqueline Kieltyka; Madelyn E. Cabãn; Gregory C. Wipf; Marie Pancera; Denise A. Galloway

doi:10.1371/journal.ppat.1013086

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Open Access

Peer-reviewed

Research Article

Human monoclonal antibodies to HPV16 show evidence for common developmental pathways and public epitopes

Joseph J. Carter ,

Contributed equally to this work with: Joseph J. Carter, Nicholas K. Hurlburt

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

https://orcid.org/0000-0001-6825-1453

⨯
Nicholas K. Hurlburt ,

Contributed equally to this work with: Joseph J. Carter, Nicholas K. Hurlburt

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Erin M. Scherer,

Roles Investigation, Resources, Writing – review & editing

Current address: Division of Infectious Disease, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Suruchi Singh,

Roles Investigation

Current address: Institute for Biology and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Justas V. Rodarte,

Roles Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Robin A. Smith,

Roles Formal analysis, Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Peter Lewis,

Roles Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Rachel Kinzelman,

Roles Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Jacqueline Kieltyka,

Roles Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Madelyn E. Cabãn,

Roles Investigation

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Gregory C. Wipf,

Roles Investigation, Supervision

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Marie Pancera,

Roles Conceptualization, Formal analysis, Funding acquisition, Visualization, Writing – review & editing

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Denise A. Galloway

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

^{^*} dgallowa@fredhuch.org

Affiliations Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Microbiology University of Washington, Seattle, Washington, United States of America

https://orcid.org/0000-0002-6713-6127

⨯

Human monoclonal antibodies to HPV16 show evidence for common developmental pathways and public epitopes

Joseph J. Carter,
Nicholas K. Hurlburt,
Erin M. Scherer,
Suruchi Singh,
Justas V. Rodarte,
Robin A. Smith,
Peter Lewis,
Rachel Kinzelman,
Jacqueline Kieltyka,
Madelyn E. Cabãn

Published: October 21, 2025
https://doi.org/10.1371/journal.ppat.1013086

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Antibodies
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HPV-16
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Chemical neutralization
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Electron cryo-microscopy
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Substitution mutation
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Human papillomavirus infection
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