Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

• Nutpakal Ketprasit ,

  Contributed equally to this work with: Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  https://orcid.org/0000-0001-8750-0187

  ⨯
• Chia-Wei Tai ,

  Contributed equally to this work with: Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• Vivek Kumar Sharma ,

  Contributed equally to this work with: Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

  ⨯
• Yogavel Manickam,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

  ⨯
• Yogesh Khandokar,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Australian Synchrotron, ANSTO, Clayton, Australia

  ⨯
• Xi Ye,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• Con Dogovski,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• David H. Hilko,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Institute for Biomedicine and Glycomics, Griffith University, Nathan, Australia, School of Environment and Science, Griffith University, Nathan, Australia

  ⨯
• Craig J. Morton,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Biomedical Manufacturing Program, CSIRO, Clayton South, Australia

  ⨯
• Anne-Sophie C. Braun,

  Roles Investigation, Writing – review & editing

  Affiliations Institute for Biomedicine and Glycomics, Griffith University, Nathan, Australia, School of Environment and Science, Griffith University, Nathan, Australia

  ⨯
• Michael G. Leeming,

  Roles Investigation, Writing – review & editing

  Affiliation Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• Bagale Siddharam,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

  ⨯
• Gerald J. Shami,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• Pushpangadan Indira Pradeepkumar,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

  ⨯
• Santosh Panjikar,

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Australian Synchrotron, ANSTO, Clayton, Australia, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

  ⨯
• Sally-Ann Poulsen,

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations Institute for Biomedicine and Glycomics, Griffith University, Nathan, Australia, School of Environment and Science, Griffith University, Nathan, Australia

  ⨯
• Michael D. W. Griffin ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: amit.icgeb@gmail.com (AS); mgriffin@unimelb.edu.au (MDWG); ltilley@unimelb.edu.au (LT); stanley.xie@monash.edu (SCX)

  ¶‡ These authors are jointly supervised this work.

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  ⨯
• Amit Sharma ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: amit.icgeb@gmail.com (AS); mgriffin@unimelb.edu.au (MDWG); ltilley@unimelb.edu.au (LT); stanley.xie@monash.edu (SCX)

  ¶‡ These authors are jointly supervised this work.

  Affiliation Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

  https://orcid.org/0000-0002-3305-0034

  ⨯
• Leann Tilley ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: amit.icgeb@gmail.com (AS); mgriffin@unimelb.edu.au (MDWG); ltilley@unimelb.edu.au (LT); stanley.xie@monash.edu (SCX)

  ¶‡ These authors are jointly supervised this work.

  Affiliation Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia

  https://orcid.org/0000-0001-9910-0199

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•  [ ... ],
• Stanley C. Xie

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: amit.icgeb@gmail.com (AS); mgriffin@unimelb.edu.au (MDWG); ltilley@unimelb.edu.au (LT); stanley.xie@monash.edu (SCX)

  ¶‡ These authors are jointly supervised this work.

  Affiliations Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia, Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

  https://orcid.org/0000-0001-7003-4677

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