IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS

• Kimia T. Maleki ,

  Contributed equally to this work with: Kimia T. Maleki, Linda Niemetz

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

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• Linda Niemetz ,

  Contributed equally to this work with: Kimia T. Maleki, Linda Niemetz

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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• Wanda Christ,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

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• Julia Wigren Byström,

  Roles Resources, Writing – review & editing

  Affiliation Department of Clinical Microbiology, Umeå University, Umeå, Sweden

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• Therese Thunberg,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Clinical Microbiology, Umeå University, Umeå, Sweden

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• Clas Ahlm,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Department of Clinical Microbiology, Umeå University, Umeå, Sweden

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• Jonas Klingström

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jonas.klingstrom@liu.se

  Affiliations Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden, Division of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

  https://orcid.org/0000-0001-9076-1441

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