Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages

• Swarnali Chakraborty ,

  Contributed equally to this work with: Swarnali Chakraborty, Debayan Ganguli, Theeya Nagaraja

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Clinical Medicine, ICMR - National Institute for Research in Bacterial Infections, Kolkata, West Bengal, India

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• Debayan Ganguli ,

  Contributed equally to this work with: Swarnali Chakraborty, Debayan Ganguli, Theeya Nagaraja

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Division of Infectious Diseases, Washington school of medicine, St. Louis, Missouri, United States of America

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• Theeya Nagaraja ,

  Contributed equally to this work with: Swarnali Chakraborty, Debayan Ganguli, Theeya Nagaraja

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliation Biocon Biologics Limited- R&D centre, Chennai, Tamil Nadu, India

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• Animesh Gope,

  Roles Data curation, Methodology, Visualization

  Affiliation Department of Clinical Medicine, ICMR - National Institute for Research in Bacterial Infections, Kolkata, West Bengal, India

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• Sudip Dey,

  Roles Data curation, Methodology

  Affiliation Department of Clinical Medicine, ICMR - National Institute for Research in Bacterial Infections, Kolkata, West Bengal, India

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• Ananda Pal,

  Roles Data curation, Project administration

  Affiliations Department of Clinical Medicine, ICMR - National Institute for Research in Bacterial Infections, Kolkata, West Bengal, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

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• Rahul Shubhra Mandal,

  Roles Data curation, Formal analysis, Software

  Affiliation Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Sudipta Sekhar Das,

  Roles Resources

  Affiliation Department of Cancer, Apollo Multispeciality Hospitals Limited, Kolkata, West Bengal, India

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• Santasabuj Das

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: santasabujdas@yahoo.com, santasabujdas@gmail.com

  Affiliations Department of Clinical Medicine, ICMR - National Institute for Research in Bacterial Infections, Kolkata, West Bengal, India, ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India

  https://orcid.org/0000-0003-0745-469X

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