Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

Parul Agrawal; Arineh Khechaduri; Kelsey R. Salladay; Anna MacCamy; Duncan K. Ralph; Andrew Riker; Andrew B. Stuart; Latha Kallur Siddaramaiah; Xiaoying Shen; Frederick A. Matsen; David Montefiori; Leonidas Stamatatos

doi:10.1371/journal.ppat.1013039

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Open Access

Peer-reviewed

Research Article

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

Parul Agrawal ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pagrawal@fredhutch.org (PA); lstamata@fredhutch.org (LS)

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Arineh Khechaduri,

Roles Investigation

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Kelsey R. Salladay,

Roles Formal analysis, Investigation

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Anna MacCamy,

Roles Formal analysis, Investigation

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Duncan K. Ralph,

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Andrew Riker,

Roles Formal analysis, Investigation

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Andrew B. Stuart,

Roles Investigation

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Latha Kallur Siddaramaiah,

Roles Investigation

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Xiaoying Shen,

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Surgical Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Frederick A. Matsen,

Roles Funding acquisition, Methodology, Project administration, resources, software, Supervision, Validation, Writing – review & editing

Affiliations Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Department of Statistics, University of Washington, Seattle, Washington, United States of America
⨯
David Montefiori,

Roles Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Division of Surgical Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Leonidas Stamatatos

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: pagrawal@fredhutch.org (PA); lstamata@fredhutch.org (LS)

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

https://orcid.org/0000-0002-1106-7097

⨯

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

Parul Agrawal,
Arineh Khechaduri,
Kelsey R. Salladay,
Anna MacCamy,
Duncan K. Ralph,
Andrew Riker,
Andrew B. Stuart,
Latha Kallur Siddaramaiah,
Xiaoying Shen,
Frederick A. Matsen

Published: May 29, 2025
https://doi.org/10.1371/journal.ppat.1013039

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