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Open Access
Peer-reviewed
Research Article
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production
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Qi Xu ,
Contributed equally to this work with: Qi Xu, Xiaoxuan Liu
Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliations State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR
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Xiaoxuan Liu ,
Contributed equally to this work with: Qi Xu, Xiaoxuan Liu
Roles Investigation, Methodology
Affiliations State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR
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Heng Heng,
Roles Data curation, Investigation, Methodology
Affiliations State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR
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Han Wang,
Roles Data curation, Investigation
Affiliations State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR
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Kaichao Chen,
Roles Data curation
Affiliation State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR
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Edward Wai-Chi Chan,
Roles Writing – review & editing
Affiliation State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR
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Guan Yang ,
Roles Conceptualization, Supervision, Writing – review & editing
* E-mail: gyang25@cityu.edu.hk (GY); sheng.chen@polyu.edu.hk (SC)
Affiliation Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR
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Sheng Chen
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: gyang25@cityu.edu.hk (GY); sheng.chen@polyu.edu.hk (SC)
Affiliations State Key Laboratory of Chemical Biology and Drug Discovery and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People’s Republic of China
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Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production
- Qi Xu,
- Xiaoxuan Liu,
- Heng Heng,
- Han Wang,
- Kaichao Chen,
- Edward Wai-Chi Chan,
- Guan Yang,
- Sheng Chen
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- Published: March 17, 2025
- https://doi.org/10.1371/journal.ppat.1012979