Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer’s disease

• Lenka Hromadkova,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Chae Kim,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Tracy Haldiman,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Mohammad Khursheed Siddiqi,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Krystyna Surewicz,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Kiley Urquhart,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Dur-E-Nayab Sadruddin,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Lihua Peng,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Xiongwei Zhu,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Witold K. Surewicz,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Mark L. Cohen,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Mark R. Chance,

  Roles Methodology, Writing – review & editing

  Affiliations Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Rohan de Silva,

  Roles Investigation, Writing – review & editing

  Affiliation Reta Lila Weston Institute of Neurological Studies and Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

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• Janna Kiselar,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliations Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Jiri G. Safar

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: jiri.safar@case.edu

  Affiliations Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Departments of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Departments of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-2209-0070

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